Table 1.

PI3K/AKT differentially expressed genes in pancreatic cancer according to the PED database. Fold-change for each probe is based on the comparison between tumour (n = 96) and normal tissue samples (n = 57) (unpaired t-test).

Pathway	Gene	Pathway Activator (↑) or Repressor (↓)	Probe	Fold-Change	p-Value	Expression Higher
PI3K/AKT	ITGA4	↑	205884_at	2.26	<0.0001	Tumour
			205885_s_at	2.21	<0.0001
	SFN	↑	209260_at	2.64	0.000154	Tumour
			33322_i_at	5.65	<0.0001
			33323_r_at	5.47	<0.0001
	PPP2R5C	↓	1557718_at	2.47	<0.05	Tumour
	PIK3CD	↑	203879_at	2.08	<0.001	Tumour
	ITGA2	↑	205032_at	3.07	<0.0001	Tumour
			227314_at	4.77	<0.0001
	PIK3R1	↑	212239_at	1.92	<0.05	Tumour
	AKT3	↑	212609_s_at	1.9	<0.0001	Tumour
			222880_at	1.58	<0.0001
	EIF4EBP1	↑	221539_at	−2.46	<0.0001	Normal Tissue
	INPP5D	↓	203332_s_at	2.11	<0.001	Tumour
	JAK2	↓	205842_s_at	2.05	<0.0001	Tumour
	MRAS	↑	225185_at	1.84	<0.0001	Tumour
	MAP2K2	↓	213490_s_at	−2.03	<0.0001	Normal Tissue
	MAP3K8	↑	205027_s_at	3.48	<0.0001	Tumour
	RAC2	↑	213603_s_at	3.51	<0.0001	Tumour
	PTEN	↓	1556006_s_at	3.88	<0.05	Tumour