Table 3.
Correlation between the 12 CpG methylation levels and gene expression in the TCGA pancreatic cancer cohort. Correlation analysis was performed in tumour samples (n = 178) for the 12 differentially methylated CpGs using the two tailed Spearman correlation.
| Pathway | Gene Symbol | Probe | Spearman r | p-Value | Correlation |
|---|---|---|---|---|---|
| PI3K/AKT | ITGA4 | cg25652029 | −0.3868 | <0.0001 | Negative |
| cg06952671 | −0.3615 | <0.0001 | Negative | ||
| cg21995919 | −0.2992 | <0.0001 | Negative | ||
| cg25024074 | −0.3396 | <0.0001 | Negative | ||
| SFN | cg17330303 | −0.5648 | <0.0001 | Negative | |
| cg13466284 | −0.5833 | <0.0001 | Negative | ||
| cg07786675 | −0.5519 | <0.0001 | Negative | ||
| cg13374701 | −0.6049 | <0.0001 | Negative | ||
| cg12583970 | −0.5921 | <0.0001 | Negative | ||
| PIK3CD | cg07805542 | 0.2534 | 0.0011 | Positive | |
| ITGA2 | cg08446038 | −0.4785 | <0.0001 | Negative | |
| PIK3R1 | cg15021292 | 0.2214 | 0.0045 | Positive |