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. 2021 Nov 26;10(12):3321. doi: 10.3390/cells10123321

Figure 4.

Figure 4

EVs derived from AML cells suppress T-cell proliferation. Purified AML derived EVs (red fields) were compared to the EV-producing cells (blue fields) and the EV-depleted soluble factors (sol F; yellow fields) for their capacity to inhibit T-cell mitogenesis in a dose-dependent manner. Abbreviations: UT, untreated peripheral blood mononuclear cells (PBMCs), from healthy donors; PHA, phytohemagglutinin-stimulated PBMCs. Paired Student’s t-test, * p < 0.05, ** p < 0.01; n = 3–8, dots represent individual experiments.