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AML-EVs inhibit NK-mediated cytotoxicity. PBMCs were treated with different doses of AML-EVs before analysis of their capacity to lyse K-562 leukemia target cells. Treatment with graded doses of purified EVs from all four AML cell lines as color-coded in the legend. Abbreviations: EVs, extracellular vesicles; PBMCs, peripheral blood mononuclear cells from healthy donors. Paired Student’s t-test, * p < 0.05, ** p < 0.01; n = 4.
