Table 3.
Association between MSI, BRAF mutation and MLH1 promoter methylation (n = 231).
| Characteristic | Microsatellite Instability | ||
|---|---|---|---|
| MSI, N = 44 | MSS, N = 187 | p-Value 1 | |
| BRAF Exon 15 | 0.031 * | ||
| Mutant | 9 (20.45%) | 16 (8.56%) | |
| Wild-type | 35 (79.55%) | 171 (91.44%) | |
| MLH1 Methylation | 0.001 ** | ||
| Methylated | 5 (11.36%) | 1 (0.53%) | |
| Unmethylated | 39 (88.64%) | 186 (99.47%) | |
| BRAF Exon 15 | |||
| Mutant, N = 25 | Wild-type, N = 206 | p-Value | |
| MLH1 Methylation | 0.13 | ||
| Methylated | 2 (8.00%) | 4 (1.94%) | |
| Unmethylated | 23 (92.00%) | 202 (98.06%) | |
1 Fisher’s exact test; * p < 0.05; ** p < 0.01.