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A model for how p53-T complex inhibits p53-mediated transcription. (Top) p53 stimulates the TFIID-TFIIA-promoter complex formation. (Bottom) T antigen represses transcription when tethered to the promoter by p53. This could occur through a conformational change of TBP within the TFIID-TFIIA-promoter complex or could be due to the exclusion of the ability of TFIIA to function as an antirepressor.
