Table 1.
Association of CXCL10/ CXCL9 with cancer prognosis in human.
| Disease | Prgnostic Association | Reference |
|---|---|---|
| Colorectal cancer (CRC) | low transcription of CXCL10 and poor prognosis in stages II and III CRC examined by snap-frozen CRC tissues by RT-PCR. | [218] |
| Rectal Cancer | Patients that are CXCL10high (RT PCR) display a better response to chemoradiotherapy, suggesting a synergistic beneficial effect of both | [219] |
| Epithelial ovarian carcinoma (HGSOC) | In patients with this disease high levels of a CXCL10 antagonist could be associated with a poor prognosis | [220] |
| Osteosarcoma (OS) | Better survival in patients with high levels of CXCL10 in circulating blood | [221] |
| Hepatocellular carcinoma (HCC) | High levels of CXCL10 in tumor tissues were associated with better prognostic and overall survival | [222] |
| Ovarian carcinoma | High levels of CXCL9 are associated with effector CD8+ T cell recruitment and good prognosis | [223] |
| ER-Negative Breast Cancer | Good prognosis associated with immune cells infiltration in suggesting CXCL9 as a potential biomarker for the prognosis of this disease | [224] |
| Breast cancer | High expression of CXCL9 and CXCL10 is associated with a good prognosis | [225] |