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. 2021 Dec 17;13(24):6356. doi: 10.3390/cancers13246356

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Mean heart dose (MHD) and heart V5 comparisons according to treatment modality and tumor location. We found that proton beam therapy (PBT) provided a statistically significantly reduced MHD and V5 as compared to the other photon-based radiotherapy techniques at each location. (A–C) Boxplots of the MHD are shown in units of absolute dose per location. (D) Boxplots of the median differences in the MHD between photon-based radiotherapy techniques and PBT. (E–G) Boxplots of the percentage of the heart receiving 5 Gy in each subgroup. (H) Median differences in the heart V5 between photon-based radiotherapies and PBT. * p ≤ 0.05; ** p ≤ 0.01; *** p ≤ 0.001; **** p ≤ 0.0001.