Table 1.

KRAS mutation subtypes and their incidence in lung adenocarcinoma.

Mutation Subtype	Codon 12 Transition or Transvertion	Aminoacid Substitution	Mutation Frequency in Lung Adenocarcinoma
G12C	G>T transversion resulting in GGT to TGT	Glycine to cysteine	44%
G12V	G>T transversion resulting in GGT to GTT	Glycine to valine	18–21%
G12D	G>A transition resulting in GGT to GAT	Glycine to aspartic acid	11–18%
G12A	G>C transvertion resulting in GGT to GCT	Glycine to alanine	8.2%
G12S	G>A transition resulting in GGT to AGT	Glycine to serine	2%
G12R	G>C transversion resulting in GGT to CGT	Glycine to arginine	1%
G12F	GG>TT transversion resulting in GGT to TTT	Glycine to phenylalanine	2%