Table 1.
Baseline characteristics of the study population.
| No. (%) Total (n = 1800) |
|
|---|---|
| Age, mean ± SD | 79 ± 6 |
| Female sex | 690 (38) |
| Tumor site | |
| Colon/rectum | 318 (18) |
| Pancreas | 52 (3) |
| Other digestive tract malignancies a | 74 (4) |
| Breast | 629 (35) |
| Prostate | 173 (10) |
| Other urinary tract malignancies b | 90 (5) |
| Lung and bronchial | 141 (8) |
| Head and neck | 62 (3) |
| Lymphoma | 205 (11) |
| Other cancers c | 56 (3) |
| Metastatic status (n = 1735) d | |
| M0 | 864 (50) |
| M1 | 502 (29) |
| Mx | 164 (9) |
| NA | 205 (12) |
| Social characteristics | |
| Living alone (n = 1793) | 719 (40) |
| Functional status | |
| ADL score ≤ 5 out of 6 (n = 1794) | 601 (34) |
| IADL score < 8 out of 8 (n = 1690) | 951 (56) |
| ECOG-PS ≥ 2 out of 4 (n = 1729) | 559 (32) |
| TGUG > 20 s (n = 1514) | 213 (14) |
| Malnutritione (n = 1774) | 1004 (57) |
| G8 score ≤ 14 (n = 1733) | 1225 (71) |
| Cognitive and emotional status | |
| MMSE < 24 out of 30 (n = 1687) | 371 (22) |
| GDS-15 ≥ 6 out of 15 or GDS4 ≥ 1 out of 4 (n = 1664) | 580 (35) |
| Comorbidity | |
| CIRS-G, median [IQR] (n = 1741) | 9 [6–13] |
| CIRS-G grade 3 or 4 (n = 1747) | 932 (53) |
| Renal insufficiency (Cockcroft-Gault, mL/min) (n = 1755) | |
| absent (clearance ≥ 60) | 831 (47) |
| moderate (30 ≤ clearance < 60) | 825 (47) |
| severe (clearance < 30) | 99 (6) |
| Inflammatory biomarkers | |
| CRP > 10 mg/L (n = 1800) | 716 (39.78) |
| CRP, median [IQR] (n = 1800) | 6 [2.70–27.25] |
| Albumin < 35 g/L (n = 1800) | 586 (33) |
| Albumin, median [IQR] (n = 1800) | 38.0 [33.00–42.00] |
| Prealbumin < 140 mg/L, (n = 1497) | 262 (18) |
| GPS (n = 1800) | |
| GPS = 0 | 921 (51) |
| GPS = 1 | 456 (25) |
| GPS = 2 | 423 (24) |
| mGPS (n = 1800) | |
| mGPS = 0 | 1084 (60) |
| mGPS = 1 | 293 (16) |
| mGPS = 2 | 423 (24) |
| CRP/albumin ratio > 0.215 (n = 1800) | 816 (45) |
| CRP/albumin ratio, median [IQR] (n = 1800) | 0.17 [0.07–0.80] |
Abbreviations: ELCAPA: elderly cancer patients; ADL: activities of daily living; IADL: instrumental activities of daily living; ECOG-PS: Eastern Cooperative Oncology Group performance status; TGUG: timed get-up-and-go test; MMSE: Mini-Mental State Examination; GDS: Geriatric Depression Scale; CIRS -G: Cumulative Illness Rating Scale; BMI: body mass index; MNA: Mini-Nutritional Assessment; CRP: C-reactive protein; GPS: Glasgow Prognostic Score; mGPS: modified Glasgow Prognostic Score; IQR: interquartile range; SD: standard deviation. a Other digestive tract malignancies: esophagus, stomach, biliary tract, hepatocellular carcinoma. b Other urinary tract malignancies: kidney, bladder, urinary tract. c Other cancer sites: skin; central nervous system, sarcoma, thyroid, unknown primary, synchronous, uterus, ovary, small intestine, peritoneal, penile, germ cell tumor. d Metastatic status: data available for n = 1530 among 1595 (lymphoma excluded); patients with lymphoma (n = 205) are considered NA with regard to metastatic status. e Malnutrition defined as any of BMI < 21 kg/m2, MNA < 17/30, albumin < 35 g/L, and recent weight loss (defined as loss of more than 3 kg in the last three months according to MNA criteria).