Figure 2.

Graphs showing number of studies that were significantly associated or not associated to response, PFS, OS plus risk of bias per article for blood biomarkers. Right part of figure shows total number of included patients. A significant response was defined as p ≤ 0.05. Abbreviations; CRP:C-reactive Protein, CTC: circulating tumor cells, ELR: eosinophil-to-lymphocyte ratio, ESR: erythrocyte sedimentation ratio, HGF: hepatocyte growth factor, LDH: lactate dehydrogenase, NLR: neutrophil-to-lymphocyte ratio, PLR: platelet-to-lymphocyte ratio, Tregs: regulatory T-cells.