Figure 1.

Bipartite network between hypoxic miRNAs and acidic-driven Mexo proteins. These miRNAs are related to hypoxia, and were generally described within Exo, but not within hypoxic Exo. The network (grey lines) displays hypoxia-associated miRNAs (hsa-mir, cyan squares; n = 57) targeting the indicated melanoma metastatic genes (green circles) whose expression was found enriched in acidic Mexo (summarized in Table 1). The red arrowheads depict miRNAs experimentally involved in melanoma progression, metastatic expansion and drug therapy resistance (summarized in Table 2). This bipartite network has been generated by interrogating the publicly available database miRNet (https://www.mirnet.ca, accessed on 30 March 2021; see Data Availability Statement for further details) within the exosome dataset (n = 1250 hsa-mir) and the indicated genes.