Table 4.

Dose-dependent changes with brain microstructure or functional connectivity.

First Author, Year	Dose-Dependent Changes
Ma Q, 2016 [36]	Functional connectivity pattern in NPC treated patients was significantly impaired compared to NPC untreated with changes shown in cerebellum, sensorimotor, and cingulo-opercular.
Qiu Y, 2017 [36]	Changes in right insular functional connectivity were negatively correlated with dose of right temporal lobe.
Ma Q, 2017 [42]	Altered cerebral-cerebral functional connectivity within dorsal attention, default, and frontoparietal networks shown in NPC treated patients.
Guo Z, 2018 [40]	Significantly decrease volume in bilateral temporal lobe with increased mean dose to this region.
Lv X, 2018 [41]	Volume deficits in the bilateral hippocampus, bilateral granule cell layer, and right molecular layer negatively correlates with the mean dose to ipsilateral hippocampus.
Ren WT, 2019 [39]	Decreased connectivity in multiple cerebellar-cerebellar regions mainly in the default-mode networks likely because of radiation dose.
Wu G, 2020 [37]	Significant radiation-induced changes in both white and gray matter of the temporal lobes due to the high radiation dose received.