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. 2021 Nov 26;10(12):3313. doi: 10.3390/cells10123313

Table 1.

Regulation of anti-tumor immuno-mediated cytotoxicity by lncRNAs expressed in cells of adaptive and innate immunity.

LncRNA Expressing
Cell
Population
Cancer
Type #
Action Effect Molecular
Targets
Ref.
SNHG1 CD4+ TILs BC IS Induces Treg polarization
Suppresses CTL activity
Induces CTL apoptosis
miR-448
/IDO
[38]
EGFR CD4+ TILs HCC IS Induces Treg polarization
Suppresses CTL propagation and activity
EGFR/AP1/
NFAT1/
Foxp3
[39]
INSR BM-infiltrating CD4+ T cells Pediatric
T-ALL
IS Increases Treg numbers
Suppresses CTL propagation and activity
INSR/PI3K/
AKT
[40]
linc-
POU3F3
Tregs GC IS Increases Treg distribution TGF-β/
SMAD2/3
[41]
Flart Tregs - IS Treg induction FoxP3 [42]
Flicr Tregs - IM Impairs Treg activity FoxP3 [43]
Linc-
MAF-4
CD4+ T
cells
- IS Promotes T cell differentiation towards a Th2 phenotype MAF [44]
SGK1 TILs GC IS Promotes Th2 and Th17 differentiation
Inhibits Th1 differentiation
SGK1/
Jun-B
[45]
NKILA CD8+ TILS
Th1 TILS
LUAD,
BC
IS Promotes CD8+ T cell AICD STAT1/NF-κB [46]
Morrbid CD8+ - IM Induces CD8+ T cell expansion and survival Bcl2111/PI3K/AKT [47]
GM16343 CD8+ T
cells
CRC IM Increases CD8+ T cell cytotoxicity IL-36 [48]
DC DCs - IM Promotes DC differentiation
and T cell stimulation
STAT3 [51,52]
Dpf3 DCs - IS Restrains CCL7-mediated
DC migration to dLNs
HIF-1α [53]
GNAS-AS1 NSCLC
BC
IS Induces M2 polarization MIR4319/NECAB3 and
GNASAS1/
miR-433-3p/GATA3
[56,57]
LIFR-AS1 Μφ OS IS Promotes CC proliferation, and invasion
Restrains CC apoptosis
miR-29a/
NFIA
[62]
Sbf2-AS1 Μφ PACA IS Cancer progression miR-122-5p/XIAP [63]
NIFK-AS1 Μφ UCEC IM Inhibits M2 Polarization miR-146a [64]
COX-2 Μφ HCC IM Inhibits M2 Polarization Not stated [65,66]
CCAT1 Μφ PRAD IM Inhibits M2 Polarization miR148a/
PKCζ
[67]
XIST Μφ LUAD IS Induces M2 polarization TCF-4 [58]
P21 Μφ BC IS Inhibits M1 polarization MDM2/p53/NFκB/
STAT3
[59]
ANCR Μφ GC IS Inhibits M1 polarization FoxO1 [60]
MM2P BMDM OS @
OV
IS Induces M2 polarization STAT6 [61]
CHOP MDSCs MM,
LUAD, BC
IS Represses CD4+ and CD8+ T cell proliferation CHOP/C/EBPB [74]
Olfr29-ps1 Mo-MDSCs MM, CRC, READ IS Promotes MDSC differentiation and T cell inhibition miR-214-3p/MyD88/M6A [75]
RNCR3 MDSCs MM IS Promotes MDSC expansion, differentiation and immunosuppressive function miR-185-5p/Chop [76]
Pvt1 G-MDSCs LUAD IS Promotes MDSC-mediated immunosuppression
Inhibits T cell responses
Arg1 and ROS [77]
RUNXOR MDSCs LUAD IS Promotes MDSC-mediated immunosuppression RUNX1/
Arg1
[78]
HOTAIRM1 MDSCs LUAD IM Inhibits MDSC-mediated immunosuppression HOXA1 [69]
MALAT1 MDSCs LUAD IM Inhibits MDSC expansion and accelerates CTL proportion Arg1 [73]
GAS5 NK HCC IM Increases NK cytotoxicity miR-544/RUNX3 [79]
RP11-222K-16.2 NK AML IM Increases NK cell differentiation and CD8+ T cell cytotoxicity Eomeso-
dermin
[80]
IFNG-AS1 NK - IM Increases NK cell activity IFN-γ [81]
Lnc-CD56 NK - IM CD34+ hematopoietic progenitor cell polarization to NK cell phenotype CD56 [82]

Abbreviations used: IS, Immunosuppression; IM, Immunomodulation; AICD, Activation induced cell death; BM, Bone marrow; CC, Cancer cell; Linc, Long intragenic non coding; Mφ; DCs, Dendritic cells; dLNs, Distant lymph nodes; Μφ, Macrophages; NK, Natural Killer cells; MDSCs, Myeloid-derived suppressor cells; mo-MDSCs, Monocytic-myeloid-derived suppressor cells; G-MDCs, Granulocytic-myeloid-derived suppressor cells; TILs, Tumor infiltrating lymphocytes; Tregs, Regulatory T cells; CTLs, cytotoxic T lymphocytes; BMDM, Bone marrow derived macrophages. # NCI-based TCGA-based abbreviations available online: https://gdc.cancer.gov/recources-tcga-users/tcga-code-tables/tcga-study-abbreviations (accessed on 13 October 2021): UCEC, Uterine corpus endometrial carcinoma; MM, Malignant melanoma; OS, Osteosarcoma; HCC, Hepatocellular carcinoma; BC, Breast Cancer; CRC, Colorectal Cancer; AML, Acute myeloid leukemia; OV, Ovarian serous cystadenocarcinoma; NSCLC, Non-small cell lung cancer; PRAD, Prostate adenocarcinoma; T-ALL, T cell acute lymphoblastic leukemia; GC, Gastric cancer; READ, Rectum adenocarcinoma; LUAD, Lung adenocarcinoma; PACA, Pancreatic cancer. @ Murine osteosarcoma.