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. 2021 Dec 10;11(12):1855. doi: 10.3390/biom11121855

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Photothermal-responsive DNA nanodevices for drug carrier. (a) UCNPs (light modulator) are used to convert NIRs of two different wavelengths (808 and 980 nm) into orthogonal ultraviolet light and up-converted light (UCL), respectively, and (b) the nanodevice recognizes nucleolin on the surface of tumor cells under local trigger of 808 nm NIR light and then generates ROS under irradiation of 980 nm NIR light for PDT, reproduced with permission from Reference [108], Copyright 2020 The Authors; (c) the encapsulation and release of HRP by a covalently closed three-dimensional DNA cage device are controlled by temperature, reproduced with permission from Reference [108], Copyright 2013 American Chemical Society.