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. 2021 Dec 10;11(12):1855. doi: 10.3390/biom11121855

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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pH-responsive DNA nanodevices for drug carrier. (a) The TDF-based programmable pH sensor using DNA i-motif as the proton recognition probe provides a continuously distributed pH response over the range of 5.0 to 7.5. and (b) the i-motif-TDF nanosensor was anchored to the cell surface for in situ pH analysis, reproduced with permission from Reference [115], Copyright 2021 American Chemical Society. (c) The triplex-DNA nanoswitch-based system responds accurately to pH changes over the 5.0–7.0 range. In an extracellular neutral space, a linear DNA nanoswitch is used for fixing a plurality of therapeutic drugs; After entering the intracellular acidic space, the DNA nanodevice changed from linear to triple to release the drug, reproduced with permission from Reference [122], Copyright 2019 American Chemical Society.