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. 2021 Dec 10;11(12):1855. doi: 10.3390/biom11121855

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Enzyme-responsive DNA nanodevices for drug carrier. (a) The enzymatic RNA generated by rolling circle transcription (RCT) was self-assembled into PRS by using cyclodextrin as a complexing agent, and SF was further carefully loaded to form porous RNA nanospheres (PRS@SF), and (b) after intravenous injection of PRS@SF, the PRS@SF was transported in blood vessels and swallowed by target cells, and the drug SF and siRNA were released for synergistic treatment after being digested by cytoplasmic Dicer enzyme, reproduced with permission from Reference [138], Copyright 2020 Elsevier. (c) MMPs induced specific and rapid assembly of PEG-Dox-attached AuNPs in vivo to enhance tumor inhibition, reproduced with permission from Reference [139], Copyright 2019 Elsevier.