Table 1.
Characteristics of included studies.
| Study (Year) | Country | Study Design | Type of Cohort | Inclusion Period | Number and Type of Cases | Inclusion Criteria dVIN |
|---|---|---|---|---|---|---|
| Yang et al. (2000) [22] | USA | Retrospective cohort study | Center-based | NA | 8 dVIN 1 | Revision of pathology slides |
| Van de Nieuwenhof et al. (2009) [18] | The Netherlands | Retrospective cohort study | Population-based | 1992–2005 | 67 dVIN | Pathology reports describing dVIN as differentiated VIN, VIN simplex type, VIN NOS with LS and/or a high-risk HPV-negative result |
| Regauer et al. (2016) [19] | Austria | Retrospective cohort study | Center-based | 2004–2016 | 16 dVIN | Revision of pathology slides |
| Thuijs et al. (2020) [7] | The Netherlands | Retrospective cohort study | Population-based | 1991–2011 | 12 dVIN | Pathology reports describing dVIN as differentiated VIN, vulvar dystrophy with atypia or simplex VIN |
| McAlpine et al. (2017) [20] | Canada | Retrospective cohort study | Center-based | 1985–2005 | 7 dVIN18 dVIN/VSCC | Revision of pathology slides |
| Eva et al. (2008) [21] | UK | Retrospective cohort study | Center-based | 2000–2005 | 44 dVIN/VSCC | Pathology reports describing dVIN adjacent to VSCC |
| Te Grootenhuis et al. (2019) [17] | The Netherlands | Retrospective cohort study | Center-based | 2000–2010 | 197 dVIN/VSCC | Revision of pathology slides |
1 Referred to as simplex VIN in the article. Abbreviations: dVIN, differentiated vulvar intraepithelial neoplasia (cases without history of vulvar cancer); dVIN/VSCC, dVIN adjacent to vulvar squamous cell carcinoma; HPV, human papillomavirus; LS, lichen sclerosus; NA, not available; NOS, not otherwise specified; UK, United Kingdom; USA, United States of America; VIN, vulvar intraepithelial neoplasia.