Figure 1.

Decoding ncRNA biology from the bench to bedside in lymphoma. Deregulation of miRNAs and lncRNAs has been shown to play an important role during the process of B-cell lymphomagenesis. MiRNAs and lncRNAs can function both as oncogenes and as tumor suppressor genes. The study of altered miRNA/lncRNA expression will permit the identification of potential candidates to be use as therapeutics (to restore tumor-suppressive miRNAs/lncRNAs) or as therapeutic targets (to inhibit the levels of oncogenic miRNAs/lncRNAs) to be tested first in preclinical models and in subsequent clinical trials in lymphoma patients.