Figure 2.

Impairing proliferation and angiogenesis of PC cells. Major molecular pathways can be targeted by siRNAs to induce apoptosis and DNA damage in PC cells. Moreover, angiogenesis responsible for PC progression can be suppressed by siRNAs in PC therapy. ProNGF, precursor of nerve growth factor; ATG, autophagy-related gene; COX2, cyclooxygenase-2; HDAC1, histone deacetylase 1; HIF-1α, hypoxia inducible factor-1α; NF-κB, nuclear factor-kappaB; siRNA, small interfering RNA; PC, prostate cancer.