Table 2.
Perinatal MSCs in human clinical trials.
| Condition/ Procedures |
Type of Study | Number of Participants |
Material | First Author; Year; Reference |
|---|---|---|---|---|
| Knee osteoarthritis | Randomized, double-blind, placebo-controlled clinical trial | 20 | Allogenic placenta-derived MSCs | Soltani; 2019; [301] |
| Hip arthroplasty | Randomized, double blind, placebo-controlled, phase I/IIa clinical trial |
20 | Allogenic placenta-derived MSCs | Winkler; 2018; [302] |
| Erectile dysfunction | Prospective, non-randomized, single-arm clinical trial |
8 | Allogenic placenta-derived MSCs | Levy; 2016; [304] |
| Chronic obstructive pulmonary disease | Prospective, non-randomized, single-arm clinical trial |
30 | Allogenic placenta-derived MSCs-derived product: Exo-d-MAPPS drug |
Harrell; 2020; [306] |
| COVID-19-induced ARDS | Prospective, non-randomized, single-arm clinical trial |
11 | Allogenic placenta-derived MSCs (5 cases) Umbilical cord-derived MSCs (6 cases) |
Hashemian; 2021; [307] |
| Acute graft-versus-host disease | Prospective, non-randomized, single-arm clinical trial |
38 | Allogenic decidua-derived MSCs | Ringden; 2018; [308] |
| Knee osteoarthritis | Single-arm, open-label clinical trial |
29 | Allogenic umbilical cord-derived MSCs | Dilogo; 2020; [309] |
| Knee osteoarthritis | Randomized, placebo-controlled, phase I/II clinical trial |
26 | Allogenic umbilical cord-derived MSCs | Matas; 2019; [310] |
| Knee osteoarthritis | Open-label, single-arm, single-center, phase I/II clinical trial with 7-year extended follow-up |
7 | Allogeneic human umbilical cord blood-derived MSCs | Park; 2017; [311] |
| Knee osteoarthritis | Randomized, placebo-controlled clinical trial |
36 | Allogenic umbilical cord-derived MSCs | Wang; 2016; [312] |
| Chronic ischemic heart disease | Randomized, double-blind clinical trial | 115 | Collagen scaffolds covered with umbilical cord-derived MSCs | He; 2020; [313] |
| Heart failure | Randomized, controlled, phase I/II clinical trial |
30 | Allogenic umbilical cord-derived MSCs | Bartolucci; 2017; [314] |
| Chronic diabetic skin ulcers | Randomized, clinical trial | 5 | Allogenic umbilical cord-derived MSCs seeded on biological scaffold | Hashemi; 2019; [315] |
| Atopic dermatitis | Prospective, non-randomized, single-arm clinical trial |
28 | Topical drugs with allogenic umbilical cord-derived MSCs conditioned media | Kim; 2020; [316] |
| Ablative CO2 fractional laser treatment | Randomized, double-blinded, controlled clinical trial |
23 | Umbilical cord blood-derived MSCs conditioned media containing serum | Kim; 2020; [317] |
| Rheumatoid arthritis | Randomized, controlled clinical trial |
119 | Allogenic umbilical cord-derived MSCs | Qi; 2020; [319] |
| Rheumatoid arthritis | Randomized, controlled, phase I/II clinical trial |
63 | Allogenic umbilical cord-derived MSCs | He; 2020; [318] |
| Rheumatoid arthritis | Prospective, phase I/II clinical trial |
64 | Allogenic umbilical cord-derived MSCs | Wang; 2019; [320] |
| Rheumatoid arthritis | Open-label, single-arm, single-center, phase Ia clinical trial |
9 | Allogenic umbilical cord blood-derived MSCs | Park; 2018; [321] |
| Lupus nephritis | Randomized, double-blind, placebo-controlled clinical trial |
18 | Allogenic umbilical cord blood-derived MSCs | Deng; 2017; [322] |
| Multiple sclerosis | Prospective, non-randomized, single-arm clinical trial |
20 | Allogenic umbilical cord-derived MSCs | Riordan; 2018; [323] |
| Cerebral palsy | Randomized, controlled clinical trial |
39 | Allogenic umbilical cord-derived MSCs | Gu; 2020; [324] |
| Autism spectrum disorder | Single-arm, phase I/II clinical trial |
20 | Allogenic umbilical cord-derived MSCs | Riordan; 2019; [325] |
| Crohn’s disease | Randomized, controlled clinical trial |
82 | Allogenic umbilical cord-derived MSCs | Zhang; 2018; [326] |
| Kidney transplantation | Multicenter, randomized, controlled clinical trial |
42 | Allogenic umbilical cord-derived MSCs | Sun; 2018; [327] |
| Acute liver allograft rejection | Randomized, controlled, clinical trial |
27 | Allogenic umbilical cord-derived MSCs | Shi; 2017; [328] |
| COVID-19 | Randomized, double-blind, placebo-controlled, phase II clinical trial |
101 | Allogenic umbilical cord-derived MSCs | Shi; 2021; [329] |
| COVID-19 | Parallel assigned controlled, non-randomized, phase I clinical trial |
18 | Allogenic umbilical cord-derived MSCs | Meng; 2020; [330] |
| COVID-19 | Single-center open-label, individually randomized, standard treatment-controlled clinical trial |
41 | Allogenic umbilical cord-derived MSCs | Shu; 2020; [331] |
| Sepsis | Single-center, open-label, dose-escalation phase 1 clinical trial |
15 | Allogenic umbilical cord-derived MSCs | He; 2018; [332] |