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. 2021 Dec 12;11(12):1868. doi: 10.3390/biom11121868

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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WRNexo^Δ display age-dependent differences in total sleep and composition. (A) Young w¹¹¹⁸ and WRNexo^Δ flies exhibit similar levels of sleep throughout the day, while aged WRNexo^Δ flies exhibit greater sleep during the light phase compared to aged w¹¹¹⁸ controls. (B) Both aged w¹¹¹⁸ and WRNexo^Δ flies exhibit decreased sleep during the day compared to young flies and aged WRNexo^Δ flies display greater sleep than age-matched w¹¹¹⁸. (C) Aged WRNexo^Δ show greater sleep fragmentation compared to w¹¹¹⁸ flies. While WRNexo^Δ and w¹¹¹⁸ exhibit similar average bout length in both young and aged flies, aged WRNexo^Δ exhibit significantly greater bouts per day compared to age matched w¹¹¹⁸ controls. (2-way ANOVA, ** p < 0.01, **** p < 0.0001, ±SD).