Table 1.

Epigenetic modifiers regulate the tumor suppressor genes (TSGs) and oncogenes important for melanoma progression.

Gene	TSG or Oncogene	Regulation Level	Epigenetic Regulation	Reference
CDKN2A	TSG	Chromatin	Promoter hypermethylation	[28,29]
MTAP	TSG	Chromatin	Promoter hypermethylation	[30,31]
PTEN	TSG	Chromatin	Promoter hypermethylation	[32,33,34,35]
		Protein	Deacetylation by HDAC6
RASSF1A	TSG	Chromatin	Promoter methylation	[36,37]
APAF-1	TSG	Chromatin	Promoter methylation	[38]
TP53	TSG	Protein	Deacetylation by HDAC6	[39]
RAS	Oncogene	Protein	Deacetylation by HDAC6 and SIRT2	[40]
ERK	Oncogene	Protein	Acetylation by the CREB-binding protein and p300 Deacetylation by HDAC6	[41]
C-JUN	Oncogene	Protein	Acetylation by p300/CBP Deacetylation by HDAC6 and HDAC8	[42,43]
MITF	Oncogene	Protein Chromatin	Acetylation by CBP/p300 Promoter methylation	[44,45,46]
MDM2	Oncogene	Protein	Deacetylation by HDAC1	[47]
BCL-2	Oncogene	Chromatin	CBP and HDAC2	[48]