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Schematic representation of the Markov model for disease progression; EDSS = Kurtzke Expanded Disability Status Scale; state A = EDSS state at the start of a model cycle; state B = EDSS state at the end of a model cycle. EDSS progression (B > A), regression (B < A) or stability (B = A) are possible. Clinical and subclinical disease activity may occur during each cycle.
