Table A7.
The proportion of simulated patients where disease activity would be detected based on individual criteria is presented in Table 1, with different threshold choices.
| EDSS Progression | Relapse Progression Using nrelapse Threshold of | Lesion Progression Using nlesion Threshold of | PBVC Progression Using α Threshold of | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| - | 1 * | 2 | 3 | 1 | 2 | 3 * | 4 | −0.40 | −0.52 * | −0.72 | |
| natural course | 22% | 35% | 17% | 8% | 64% | 56% | 48% | 43% | 66% | 49% | 21% |
| low efficacy DMT | 19% | 30% | 12% | 5% | 64% | 43% | 38% | 28% | 66% | 49% | 21% |
| high efficacy DMT | 12% | 20% | 6% | 2% | 48% | 28% | 15% | 11% | 19% | 5% | 0% |
The * superscript indicates the selected threshold.