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. 2021 Dec 23;16(12):e0261746. doi: 10.1371/journal.pone.0261746

Table 6. Association between psychosocial stress and composite neuroendocrine biomarker index among monoracial non-Hispanic Black women overall and by HIV serostatus (n = 48).

Unadjusted model Full model a Parsimonious Model b
β (95% CI) p β (95% CI) p β (95% CI) p
Overall (n = 48)
Psychosocial stress latent profile membership
 Low ref ref ref
 Moderate 0.53 (-0.06, 1.13) 0.078 0.30 (-0.42, 1.03) 0.40 0.33 (-0.24, 0.90) 0.25
 High 0.73 (-0.11, 1.57) 0.088 1.32 (0.20, 2.43) 0.022 1.31 (0.41, 2.21) 0.0053
Among WLWH (n = 31)
Psychosocial stress latent profile membership
 Low ref ref ref
 Moderate 0.37 (-0.35, 1.09) 0.30 0.13 (-1.41, 1.68) 0.86 0.06 (-0.76, 0.88) 0.88
 High 0.98 (0.01, 1.96) 0.049 1.93 (0.02, 3.83) 0.048 1.64 (0.54, 2.73) 0.0052
Among HIV-negative women (n = 17)
Psychosocial stress latent profile membership
 Low ref ref ref
 Moderate 0.72 (-0.37, 1.81) 0.18 0.36 (-0.66, 1.38) 0.38 0.32 (-0.41, 1.06) 0.32
 High 0.17 (-1.52, 1.86) 0.84 2.54 (0.41, 4.67) 0.030 2.51 (0.93, 4.08) 0.0080

Abbreviations: CI, confidence interval; WLWH, women living with HIV; ref, reference group.

Bolded numeric values indicate p<0.05.

a Adjusted for HIV status (only in the overall sample), age, education at study entry, income, current smoking, alcohol use, recent substance use, use of a prescribed psychotropic medication, body mass index, menopausal status, CD4+ T cell count (only among WLWH), and HIV viral load (only among WLWH).

b In the overall sample, adjusted for HIV status, age, income, alcohol use, recent substance use, and body mass index. Among WLWH, adjusted for age, recent substance use, use of a prescribed psychotropic medication, and HIV viral load. Among HIV-negative women, adjusted for age, education at study entry, current smoking, alcohol use, recent substance use, body mass index, and menopausal status.