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. 2021 Dec 7;13(24):6152. doi: 10.3390/cancers13246152

Figure 3.

Figure 3

Autophagy Inhibitors and their site of action in autophagic machinery. MRT68921 and SBI-0206965 are ULK-1 inhibitors. 3-MA, Wortmannin and LY294002 are Class III PI3K inhibitors. Spautin-1 is a Beclin-1 inhibitor and SAR405 is a Vps34 inhibitor. Chloroquine (CQ) and hydroxyl chloroquine (HCQ) are late autophagy inhibitors which target lysosomal pH rendering the fusion between autophagosome and lysosome. Green arrow indicates activation and red arrow indicates inhibition. Created with BioRender.com (accessed on 15 October 2021).