Figure 1.

Timeline administration of drug, behavioral assessments, and isolation of brain samples. The groups of the mice were administered vehicle or clobenpropit (1 or 3 mg/kg) orally for 30 days. Except for the control, other groups were injected with four doses of LPS (250 μg/kg, i.p.) to induce neuroinflammation (days 23–26). Regarding RAM assessments, the training sessions were conducted from days 24 to 26. The memory assessments were analyzed from days 27 to 30. At the end of the memory assessments, on day 30, all the animals were sacrificed and brain tissues were collected for ELISA tests.