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. 2021 Dec 8;11(12):1617. doi: 10.3390/brainsci11121617

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of clobenpropit (CLO) on cyclooxygenase-2 (COX-2) levels in lipopolysaccharide (LPS)-induced mice brains. LPS-CLO-1 and LPS-CLO-3 refer to administration of clobenpropit (1 or 3 mg/kg, p.o., respectively) and lipopolysaccharides (250 μg/kg, i.p.). CLO treatment reduced the activity of COX-2 induced by LPS. The results are expressed as mean ± SEM (n = 6). One-way ANOVA (F(3,20) = 33.67, p < 0.001) was followed by Tukey–Kramer multiple comparisons tests. *** p < 0.001 as compared to the control group; ns, not significant as compared to the control group; ^### p < 0.001 as compared to the LPS-treated group.