Table 2. Particle size, PDI and zeta potential analysis of blank PEtOx NPs and different amounts of CIP-loaded PEtOx NPs (data presented as mean ± S.D., n = 3).

Formulation	Z-average size d before freeze-drying (nm)	Z-average size d after freeze-drying (nm)	PDI before freeze-drying	PDI after freeze-drying	Zeta potential before freeze-drying (-mv)	Zeta potential after freeze-drying (-mv)
Blank PEtOx	151.6 ± 1.7	196.7 ± 24.0	0.25 ± 0.1	0.35 ± 0.1	20.2 ± 1.4	30.5 ± 2.0
5 mg CIP-PEtOx	159.4 ± 4.5	299.7 ± 18.2	0.19 ± 0.0	0.31 ± 0.0	17.9 ± 0.8	28.1 ± 1.5
10 mg CIP-PEtOx	185.6 ± 0.5	317.4 ± 27.6	0.21 ± 0.0	0.31 ± 0.0	14.4 ± 1.7	25.8 ± 1.0
15 mg CIP-PEtOx	199.0 ± 1.8	353.0 ± 55.1	0.32 ± 0.0	0.28 ± 0.1	12.9 ± 0.5	22.3 ± 0.7
20 mg CIP-PEtOx	189.8 ± 5.3	249.0 ± 52.2	0.29 ± 0.1	0.33 ± 0.1	10.8 ± 1.3	21.2 ± 0.9
25 mg CIP-PEtOx	169.9 ± 3.3	200.0 ± 22.0	0.19 ± 0.0	0.33 ± 0.0	9.1 ± 0.2	18.5 ± 0.8