Table 5. Kinetics of CIP release from CIP-loaded PEtOx NPs.

Kinetics model	5 mg CIP-loaded NPs	10 mg CIP-loaded NPs	15 mg CIP-loaded NPs	20 mg CIP-loaded NPs	25 mg CIP-loaded NPs
Zero-order (F = k 0 t)
k 0	0.3537	0.4003	0.4072	0.3908	0.3725
r 2	0.5995	0.6444	0.6585	0.6836	0.6923
First-order (ln(1−F) = −k 1 t)
k 1	0.003	0.0032	0.0034	0.0034	0.0034
r 2	0.7264	0.7396	0.779	0.8018	0.8172
Higuchi $(\mathit{F}={\mathit{k}}_{\mathit{H}}{\mathit{t}}^{\frac{\mathbf{1}}{\mathbf{2}}})$
k H	5.4318	6.041	6.145	5.8807	5.5959
r 2	0.7789	0.8087	0.8264	0.8528	0.8609
Hixson-Crowell $(\mathbf{1}-{\left(\mathbf{1}-\mathit{F}\right)}^{\frac{\mathbf{1}}{\mathbf{3}}}={\mathit{k}}_{\frac{\mathbf{1}}{\mathbf{3}}}\mathit{t})$
${\mathit{k}}_{\frac{\mathbf{1}}{\mathbf{3}}}$	0.0085	0.0091	0.0097	0.0095	0.0094
r 2	0.6829	0.7058	0.7377	0.7623	0.7762
Korsmeyer-Peppas (F = K k−p t n )
k	8.216	8.681	8.3912	6.0215	5.6124
n	0.5756	0.7074	0.7025	0.5997	0.4368
r 2	0.8351	0.9077	0.8917	0.8511	0.9096