Skip to main content
. 2021 Nov 26;10(12):3314. doi: 10.3390/cells10123314

Figure 2.

Figure 2

Genome-wide transcriptional changes in the hippocampi of SD mice. (A) Volcano plot shows the Log2 (fold-change) and Log2 (p-value) of the genes. DEGs are highlighted with red color. (B) Heatmap shows the Z-scored expression value of identified DEGs. We identified 226 UpRGs and 90 DownRGs in the SD mice. (C) Top 25 GO analysis results of DEGs. P-value is indicated by the color of points and the size of points is a proportion of the odds ratio. Negative log2 (combined score) indicates the pathway analyzed from the downregulated gene set. (D) DEGs network (protein–protein interaction from STRING v11.5), we found there were 7 upregulated and 6 downregulated genes that are included in the SFARI database. UpRGs are circled in red: slc29a4, magel2, fam92b, pon1, ttc25, dydc2, ppp1r1b; DownRGs are circled in green: satb2, rora, foxp2, rims3, ttn, tcf7l2. (E) Validation results of identified SFARI-overlapped DEGs by qRT-PCR. n = 3 in CTR and SD. ** p < 0.01; * p < 0.05 vs. CTR.