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. 2021 Dec 13;11(12):1643. doi: 10.3390/brainsci11121643

Figure 3.

Figure 3

Long-term GW2580 treatment after SCI reduces IBA1 immunoreactivity in the injured spinal cord. Representative micrograph of IBA1 immuno-staining at the lesion epicenter (A). Zoomed-in micrographs in the lesion site (B), the grey matter (D), the white matter (G), and the dorsal funiculus (J) at the lesion epicenter. Six weeks after SCI, quantifications of IBA1 immunoreactivity were done in the lesion site (C), the grey matter (E,F), the white matter (H,I), and the dorsal funiculus (K,L). Optical densities were measured rostral (E,H,K) and caudal to the lesion site (F,I,L), ipsilateral, and contralateral to the lesion site. Results are expressed as mean ± SEM in untreated (blue) and GW2580-treated groups (green). Each dot corresponds to a minimum of 9 sections (630 µm interval between each section) analyzed per animal. Statistics: Student’s unpaired t-test. Number of mice: 8 for the untreated group and 7 for the GW2580-treated group. * p < 0.05; ** p < 0.01. scale bars: 500 µm (A); 100 µm (B,D,G,J); 20 µm (G) ( right bottom corner).