Figure 1.

Schematic representation of the implemented systems biology workflow. (1) First, we characterized myocardial infarction (MI) at the molecular level via manual curation of the literature and using a compendium of massive public databases describing the molecular interactions of interest. (2) In parallel, we used experimental transcriptomic data to define the molecular behavior of MI at each time point. (3) We used the information to generate a map of proteins regulated by the obtained experimental data. (4) We fed the mathematical models to identify patterns in the data, (5) identify key regulatory proteins, and (6) predict new mechanisms of action. (7) The final result included a scientific justification of every prediction. ANN: artificial neural network.