Table 3.
Best combinations differentiating infarcted and non-infarcted hearts using data from C6, C30, and C45.
| C6 | Uniprot | Protein Name | Generalization Capability | Accuracy | Type of Results | Secreted a | Related to MI b |
|---|---|---|---|---|---|---|---|
| Combination 1 | P19838 | NFKB1 | 100% | 100% | Models/HT | ✓ | ✓ |
| O14641 | DVL2 | ✓ | × | ||||
| Q06187 | BTK | ✓ | × | ||||
| P01100 | FOS | ✓ | ✓ | ||||
| P61981 | 1433G | ✓ | × | ||||
| Combination 2 | P53778 | MAPK12 | 100% | 100% | Models/HT | ✓ | ✓ |
| Q9Y243 | AKT3 | ✓ | ✓ | ||||
| P28482 | MAPK01 | ✓ | ✓ | ||||
| P19838 | NFKB1 | ✓ | ✓ | ||||
| P45984 | MAPK09 | ✓ | ✓ | ||||
| C30 | |||||||
| Combination 1 | P62942 | FKB1A | 100% | 100% | Models/HT | ✓ | ✓ |
| Q14790 | CASP8 | ✓ | ✓ | ||||
| Combination 2 | P62942 | FKB1A | 100% | 100% | Models/HT | ✓ | ✓ |
| P30559 | OXYR | ✓ | ✓ | ||||
| C45 | |||||||
| Combination 1 | P27487 | DPP4 | 100% | 100% | Models/HT | ✓ | ✓ |
| O75330 | HMMR | ✓ | ✓ | ||||
| P03952 | KLKB1 | ||||||
| P07203 | GPX1 | ||||||
| P31645 | SLC6A4 | ||||||
| Combination 2 | P62942 | FKB1A | 100% | 100% | Models/HT | ✓ | ✓ |
| P03952 | KLKB1 | ✓ | ✓ |
a Indicates whether the protein is secreted and/or has been detected in plasma. b Indicates if there is a previously known relationship between the protein and MI. Models/HT: the combinations of proteins that better classify the solution of the model to the corresponding cohort filtered by the proteins according to the high-throughput (HT) data; MI: myocardial infarction; C6: infarct core area 6 days after infarction; C30: infarct core area 30 days after infarction; C45: infarct core area 45 days after infarction.