Table 2.

Incidence of left ventricular (LV) dysfunction associated with selected chemotherapy agents.

Chemotherapy Agent	Incidence of LV Dysfunction
Anthracyclines
Doxorubicin [34]
400 mg/m2	3–5%
550 mg/m2	7–26%
700 mg/m2	18–48%
Epirubicin [35]
>900 mg/m2	0.9–11.4%
Alkylating agents
Cyclophosphamide [36]	7–28%
Ifosfamide [37]
<10 g/m2	0.5%
10–18 g/m2	17%
Antimicrotubule agents
Docetaxel [38]	2.3–8%
Paclitaxel [25]	1–10%