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. 2021 Dec 7;10(12):3444. doi: 10.3390/cells10123444

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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CORM-3 increases Nrf2 and HO-1 expression. Murine BMCs were treated with 100 μM CORM-3 on day 5 and incubated for 5 days to induce macrophage differentiation. (A,B) Gene expression of Nrf2 and HO-1 was measured using qRT-PCR (n = 3). (C) The protein levels of Nrf2 (n = 3), HO-1 (n = 5), and Prx1 (n = 4) in differentiated macrophages were determined by immunoblotting and (D) the relative densities were calculated as the ratio to β-actin. Results are presented as mean ± SD; * p < 0.05, ** p < 0.01, and *** p < 0.001 compared to control, and ^# p < 0.05 between groups compared with Student’s t-test for (A,B) or one-way ANOVA for (D).