Figure 2.
Variation of expression of some of the genes of the kynurenine (A) and serotonin (B) pathways in HB. See legend to Figure 1 for the abbreviations. AANAT and ASMT, coding both for melatonin-synthesizing enzymes, are barely detectable in both non-tumor and tumor samples while TPH1 expression is increased in tumor samples. In HB, the 5-HT pathway would be reduced to 5-HTP production readdressing the question of the balance between KYN and 5-HT pathways in these tumors. (ns, not significant; *,1 × 10−2 < p < 5 × 10−2; ***, 1 × 10−4 < p < 1 × 10−3; **** p < 1 × 10−4).