Figure 4.

The influence of two-week treatment with iloperidone on the mRNA levels of the CYP2D4 gene in the selected brain structures and on the mRNA levels of the CYP2D1, CYP2D2 and CYP2D4 genes in the liver. The results are expressed as the fold change compared to the ACTB housekeeping gene. The presented values are the mean fold change quantified by the comparative delta-delta Ct method for the control and iloperidone-treated rats (mean ± S.E.M. of 12 samples (from 12 animals) for the cerebellum, remainder of brain and the liver, of 6 samples (each sample contained 2 pooled brain structures from 2 animals) for the frontal cortex, brain stem, striatum and hippocampus or of 4 samples (each sample contained 3 pooled brain structured from 3 animals) for the hypothalamus, nucleus accumbens and substantia nigra). Student’s t-test: * p < 0.05 vs. control group. FCx—the frontal cortex, St—the striatum, NA—the nucleus accumbens, Hp—the hippocampus, Ht—the hypothalamus, Bs—the brain stem, SN—the substantia nigra, Cb—the cerebellum and RM—the remainder.