Table 1.
The CYP2D activity, protein and mRNA levels in the selected brain structures and liver.
| Tissue | CYP2D Activity (% of Control) |
CYP2D Protein Level (% of Control) |
CYP2D mRNA Level (% of Control) | |||
|---|---|---|---|---|---|---|
| CYP2D1 | CYP2D2 | CYP2D4 | ||||
| Brain structures | FCx |
67 ± 2.7 ↓ * |
78 ± 12.4 ↓ * |
n.t. | n.t. | 101 ± 17.5 |
| St |
124 ± 9.5 ↑ * |
181 ± 21.1 ↑ * |
n.t. | n.t. |
153 ± 9.4 ↑ * |
|
| NA |
136 ± 5.1 ↑ * |
159 ± 20.3 ↑ * |
n.t. | n.t. | 115 ± 23.8 | |
| Hp | 99 ± 13.6 | 105 ± 14.9 | n.t. | n.t. | 111 ± 18.9 | |
| Ht | 93 ± 4.7 | 107 ± 15.9 | n.t. | n.t. | 114 ± 11.2 | |
| Bs | 90 ± 8.1 | 95 ± 12.8 | n.t. | n.t. | 121 ± 7.1 | |
| SN |
126 ± 13.7 ↑ * |
148 ± 9.9 ↑ * |
n.t. | n.t. | 123 ± 16 | |
| Cb |
79 ± 8 ↓ * |
80 ± 8.5 ↓ * |
n.t. | n.t. | 93 ± 13.8 | |
| RM | 97 ± 8.7 | 99 ± 10.8 | n.t. | n.t. | 103 ± 8.6 | |
| Liver |
67 ± 5.3 ↓ * |
82 ± 4.1 ↓ * |
78 ± 4.1 ↓ * |
71 ± 4.8 ↓ * |
82 ± 4.7 ↓ * |
|
↑, ↓ Increase or decrease, respectively; n.t.—not tested. Student’s t-test: * p < 0.05 vs. control group. FCx—the frontal cortex, St—the striatum, NA—the nucleus accumbens, Hp—the hippocampus, Ht—the hypothalamus, Bs—the brain stem, SN—the substantia nigra, Cb—the cerebellum and RM—the remainder. For further explanation, see Figure 2, Figure 3 and Figure 4.