Figure 1.

Humoral response to two and three vaccine doses

(A) Anti-RBD antibody concentrations in controls, patients who had received at least two doses, patients who had received two doses and would later receive a third, and patients who had received three doses. The violin illustrates the kernel probability density and the orange line indicates the median. Dots denote individual patients. (B) Time between last rituximab infusion and first vaccine dose according to response status in all patients after their second vaccine dose. The violin illustrates the kernel probability density and the orange line indicates the median. Dots denote individual patients. (C) Anti-RBD antibody concentrations after the second and third doses. Solid lines connect patients' two samples (circles). The horizontal dotted line indicates the cutoff for positivity (70 AU/mL). (D) Time between the last rituximab infusion and anti-RBD response after the third vaccine dose. AU=arbitrary units. RBD=receptor-binding domain.