Figure 2.

Modulating microglia and macrophage for therapy. Many novel therapeutic approaches have emerged to promote remodeling of the injured brain in stroke models by altering the activation phenotype of microglia and macrophages. Methods for alternative activation of microglia and macrophages include but are not limited to the use of various small molecules, partial MHC class II constructs, stem cell therapies as well as transplantation of microglia as a treatment for both the acute and chronic effects of stroke. Created with BioRender.com.