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Reduced whole-body adiposity and increased energy expenditure in L1-KO mice fed the HFD for 23–25 weeks: (A,B) fat body mass and its ratio to BW (A) and lean body mass and its ratio to BW (B) in L1-KO mice (n = 10) and WT littermates (n = 9); (C–G) food intake (C), oxygen (O2) consumption (D), carbon dioxide (CO2) production (E), energy expenditure (F), and respiratory exchange ratio (RER) (G) in L1-KO mice (n = 15) and WT littermates (n = 12). * p < 0.01, ** p < 0.000001.
