Table 1.

Gross manifestations of splenic neoplasms.

	Low-Grade CD5(−)CD10(−) B-Cell LPDs	Other Neoplasms
Diffuse miliary small white nodules	Splenic marginal zone lymphoma	Follicular lymphoma Mantle cell lymphoma CLL/SLL Classic Hodgkin lymphoma, rarely
Large mass-like nodules, solitary or multiple		Diffuse large B-cell lymphoma, follicular lymphoma, usually higher grade, classic Hodgkin lymphoma; Vascular neoplasms including littoral cell angioma, hemangioma, and splenic hamartoma
Homogeneous, beefy red cut surface	Hairy cell leukemia, hairy cell leukemia variant, splenic diffuse red pulp small B-cell lymphoma	Hepatosplenic T-cell lymphoma, T-cell prolymphocytic leukemia

Abbreviations: CLL/SLL = chronic lymphocytic leukemia/small lymphocytic lymphoma; low grade CD5(−)CD10(−) B-cell LPDs = low grade CD5 negative, CD10 negative LPDs.