Table 3.

Key morphologic features of CD5-CD10-LPDs, [7,72].

Neoplasm	Peripheral Blood	Bone Marrow	Spleen
SRDPL	Mature lymphocytes with villous projections	Intrasinusoidal pattern of involvement. No plasmacytic differentiation	Cord and sinusoidal expansion +/− blood lakes
HCL	Lymphocytes (less chromatin clumping than normal lymphocytes) with villous projections	Subtle to extensive interstitial infiltrates of lymphocytes. Often extensive reticulin fibrosis	Red pulp cord expansion; atrophic white pulp; blood lakes common.
HCL-v	Small lymphocytes with visible nucleoli and villous projections	Intrasinusoidal pattern of involvement; atrophic white pulp	Fill dilated sinusoids +/− blood lakes; atrophic white pulp
LPL/WM	Spectrum of lymphocytes, plasmacytoid lymphocytes, and true plasma cells.	Diffuse, interstitial, and nodular involvement by a spectrum of lymphocytes, plasmacytoid lymphocytes, and true plasma cells	Red pulp cord and sinus expansion; atrophic white pulp.

Abbreviations: HCL-v = hairy cell leukemia variant, LPL/WM = lymphoplasmacytic lymphoma/Waldenström macroglobulinemia, SRDPL = splenic diffuse red pulp small B- cell lymphoma.