Table 1.
Features of NET G3 patients.
| Variable | Level | NET G3 | p-Value | Overall (N = 30) | |
|---|---|---|---|---|---|
| Upfront (N = 22) | Late (N = 8) | ||||
| Age (y), N (%) | <50 | 7 (32) | 2 (25) | 1.00 | 9 (30) |
| 50+ | 15 (68) | 6 (75) | 21 (70) | ||
| Median (min–max) | 55 (34–70) | 56 (44–61) | 0.85 | 56 (34–70) | |
| Sex, N (%) | F | 7 (32) | 6 (75) | 0.049 | 13 (43) |
| M | 15 (68) | 2 (25) | 17 (57) | ||
| Primary site of disease, N (%) | Pancreas | 13 (59) | 7 (88) | 0.85 | 20 (67) |
| Ileum | 3 (14) | 0 (0) | 3 (10) | ||
| Rectum | 2 (9) | 0 (0) | 2 (7) | ||
| Stomach | 2 (9) | 1 (13) | 3 (10) | ||
| Unknown-primary | 2 (9) | 0 (0) | 2 (7) | ||
| Ki-67, N (%) | ≤30 | 10 (45) | 6 (75) | 0.23 | 16 (53) |
| >30 | 12 (55) | 2 (25) | 14 (47) | ||
| Median (min–max) | 33 (21–70) | 30 (23–45) | 0.34 | 30 (21–70) | |
| Functioning, N (%) | No | 18 (82) | 7 (88) | 1.00 | 25 (83) |
| Yes | 4 (18) | 1 (13) | 5 (17) | ||
| 68Ga-DOTA-TOC PET/CT, N (%) | Negative | 2 (9) | 0 (0) | 1.00 | 2 (7) |
| Positive and inhomogeneous | 4 (18) | 1 (13) | 5 (17) | ||
| Positive and homogeneous | 16 (73) | 7 (88) | 23 (77) | ||
| 18F-FDG-PET/CT, N (%) | Negative | 5 (23) | 0 (0) | 0.47 | 5 (17) |
| Positive and inhomogeneous | 7 (32) | 4 (50) | 11 (37) | ||
| Positive and homogeneous | 10 (45) | 4 (50) | 14 (47) | ||
| Concordance Ga-FDG, N (%) | <75% | 16 (73) | 5 (63) | 0.67 | 21 (70) |
| ≥75% | 6 (27) | 3 (38) | 9 (30) | ||
| Prevalence, N (%) | 68Ga-DOTA-peptide PET/CT | 11 (50) | 4 (50) | 0.76 | 15 (50) |
| 18FDG-PET/CT | 6 (27) | 1 (13) | 7 (23) | ||
| None | 5 (23) | 3 (38) | 8 (27) | ||
| T non-T, N (%) | <4 | 9 (53) | 4 (50) | 1.00 | 13 (52) |
| ≥4 | 8 (47) | 4 (50) | 12 (48) | ||
| Median (min–max) | 4.0 (1.8–8.9) | 5.4 (1.6–13.0) | 0.68 | 4.0 (1.6–13.0) | |
1 Among 8 patients with late NET G3, this was the distribution of the years between first diagnosis and G3 diagnosis: Median (min–max): 4.0 (2.3–8.0). 2 For “Late NET G3”, values “after” of 68Ga-DOTA-peptide PET/CT, 18FDG-PET/CT, concordance Ga-FDG, prevalence, and T non-T were considered. 3 For “Late NET G3”, this was the distribution of “before” and “after” values of T non-T: “Before”: Median (min-max): 3.0 (2.4–4.0). “After”: Median (min-max): 5.4 (1.6–13.0).