Table 1.

Case reports of pediatric ASD patients with neuroleptic malignant syndrome in the literature: demographic and clinical features.

	AGE	SEX	ASD	ID	AP	Preceding Catatonia	Other Symptoms	Reference
Patient 1	17	F	Yes	Yes	risperidone for 4.5 years, haloperidol and ziprasidone as needed	Yes	Restlessness, aggression, mutism, diaphoresis, sleep disturbances	Ghaziuddin et al., 2017 [18]
Patient 2	12	M	Yes	Yes	risperidone, quetiapine, ziprasidone, olanzapine	Yes	Restlessness, SIB, aggression, sleep disturbances	Ghaziuddin et al., 2017 [18]
Patient 3	15	F	Yes	Yes	ziprasidone, chlorpromazine	Yes	Posturing, aggression, mutism	Ghaziuddin et al., 2017 [18]
Patient 4	9	M	Yes	Yes	risperidone 1.5 mg/die, loxapine IM 30 mg/die	Yes	SIB, aggression, posturing, anorexia	González-Romero et al., 2019 [19]
Patient 5	16	M	Yes	Yes	aripiprazole 10 mg/die, quetiapine 250 mg/die, lorazepam	Yes	Anorexia, asthenia, perioral myokymia and myoclonus, difficulty swallowing, polypnea	This issue

Notes: ASD = autism spectrum disorder; ID = intellective disability; SIB = self-injurious behavior; AP = antipsychotic.