Table 2.
Gene | Exon(s) | Codon Position | Number of Hotspots |
---|---|---|---|
KRAS | 2 | 12, 13 | 2 |
3 | 59, 61 | 2 | |
4 | 117, 146 | 2 | |
NRAS | 2 | 12, 13 | 2 |
3 | 59, 61 | 2 | |
4 | 117, 146 | 2 | |
MET | 14 | 1003 | 1 |
BRAF | 15 | 600 | 1 |
ERBB2 | 8 | 309, 310 | 2 |
19 | 740, 755, 767, 769 | 4 | |
20 | 773, 776, 777 | 3 | |
21 | 824, 842, 874 | 3 | |
EGFR | All exons (1–28) including 12 | 451, 464, 465, 467, 491, 492 | 6 |