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The p73-regulated signalling pathways influence EMT, mobility, or invasiveness in cancer models. In blue shown is the EMT repressive and in red—the EMT-promoting signalling. TAp73 inhibits EMT, mobility, and invasion for breast [116], colorectal [89,120,126] or pancreatic cancers [121,122]. However, the induction of DNp73 inhibits EMT and metastasis in melanoma [127,128]. In glioblastoma, total p73 depletion induces an invasive phenotype in the POSTN-dependent manner [135].
