Table 6.
Association between enhancer rs4693608 and insulator rs28649799 and the number of CD34+ cells following administration of G-CSF to healthy donors after the first apheresis.
| SNPs | Parameters | CMV-Seropositive | CMV-Seronegative | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Genotype | Median (Range) | Comparisons to Carriers |
p-Value | Genotype | Median (Range) |
Comparisons to Carriers |
p-Value | ||
| rs4693608 | CD34+ × 106 total yield | AA (48) | 828.9 | AA to GG | 0.013 | AA (25) | 753.9 | AA to GG | 0.55 |
| (718.2–930.0) | (518.0–1008.0) | ||||||||
| AG (72) | 711.4 | AA to others | 0.022 | AG (20) | 878 | AA to others | 0.73 | ||
| (623.7–784.7) | (634.0–1062.0) | ||||||||
| GG (38) | 629.2 | GG to others | 0.052 | GG (12) | 781.3 | GG to others | 0.39 | ||
| (502.5–729.4) | (365.8–1184.0) | ||||||||
| % CD34+ | AA (47) | 0.9 | AA to GG | 0.022 | AA (25) | 0.86 | AA to GG | 0.88 | |
| (0.77–1.02) | (0.65–1.12) | ||||||||
| AG (72) | 0.73 | AA to others | 0.007 | AG (20) | 1.05 | AA to others | 0.34 | ||
| (0.7–0.81) | (0.85–1.34) | ||||||||
| GG (37) | 0.74 | GG to others | 0.23 | GG (12) | 0.82 | GG to others | 0.5 | ||
| (0.6–0.85) | (0.65–1.18) | ||||||||
| rs28649799 | CD34+ × 106 total yield | AA (121) | 735.7 | AA to AG | 0.089 | AA (39) | 786.5 | AA to AG | 0.3 |
| (659.7–784.7) | (542.8–882.8) | ||||||||
| AG (21) | 854 | AG (10) | 1020.7 | ||||||
| (648.0–1143.1) | (368.9–1485.7) | ||||||||
| % CD34+ | AA (120) | 0.76 | AA to AG | 0.031 | AA (39) | 0.88 | AA to AG | 0.32 | |
| (0.72–0.83) | (0.66–1.12) | ||||||||
| AG (21) | 0.97 | AG (10) | 1 | ||||||
| (0.7–1.14) | (0.57–1.7) | ||||||||
Significant deviations (p < 0.05) and trend to significance are marked in bold.